The Death Of Sickle Cell Disease - 1755 Words

The purpose of this essay it to determine whether or not Jonathon Jackson, a 30 year old air traffic controller whom has been faithful to his company and job for over eight years that has recently discovered he has sickle cell anemia, should be dismissed from his job regarding his genetic test results. Sickle cell anaemia is the most severe form of sickle cell disease and is a genetic disease of the red blood cells (Gibbons, 2015). Red blood cells have a disk like form which allows them the ability to travel through blood vessels. Although in people with sickle cell, the red blood cells form an abnormal crescent shape which makes them rigid and sticky as shown in Diagram 3 below. This causes the sickled cells to get trapped in small vessels which blocks blood from reaching different parts of the body leading to pain, tissue damage and many more symptoms (University of Utah, 2015). The term anaemia comes from having a shortage of red blood cells in your blood which occurs because sic kled cells only last up to 10- 20 days while normal red blood cells last approximately 120 days. The name ‘sickle’ comes from an old farm tool known as a sickle as shown in Diagram 4 below which represents the same shape as curved sickled cells (Petch, 2012). Sickle cell disease affects millions of people worldwide and is most common in those who have ancestors from Africa, the Mediterranean, The Arabian Peninsula and Spanish speaking areas in South America. People with sickle cell anaemia onShow MoreRelatedPrevalence Of Sickle Cell Anemia1639 Words   |  7 PagesEzeocha PREVALENCE OF SICKLE CELL ANEMIA IN THE UNITED STATES OF AMERICA According to Sickle Cell Disease American Association sickle cell anemia defined as an inherited blood disorder that alters red blood cells. Patients with sickle cell disease have their red blood cells contaminated with an abnormal kind of hemoglobin called the Hemoglobin S. The National Institute of Health (NIH), reports that this anomalous behaviour of the hemoglobin S reduces the red blood cell into a sickle shape which becomesRead MoreAfrican American Parents With The Sickle Cell Trait1524 Words   |  7 PagesAfrican-American parents with the Sickle Cell Trait have the greatest risk of passing Sickle Cell Anemia to their offspring. In this article, sickle cell anemia is defined as a hereditary disease that destroys red blood cells by causing them take on an elongated and rigid sickle shape. In addition, a different type of hemoglobin called Hemoglobin S, is the protein in red blood cells that carry oxygen throughout the body. This protein starts to wrap around other red blood cells when oxygen is lacking toRead More Discovering Sicke Cell Anemia Essay1320 Words   |  6 PagesDiscovering Sicke Cell Anemia The topic that I am learning about is Sickle Cell Anemia, a hereditary disease which affects red blood cells. Throughout this research paper, I will discuss what exactly it is, how it is caused, any known treatments or cures, and many other facts that are important in this disease. Sickle Cell Anemia is a health problem throughout the world. More than 250,000 babies are born worldwide with this inherited blood cell disorder (http://www.medaccess.com/h_child/sickle/sca_01.htm)Read MoreCell Signaling Essay1583 Words   |  7 PagesDefects of Cell Signaling Over the past semester in cell biology, determining protein structure and functions of gene sequences have been some important discussions in class. On this discussion, many people will agree that the defects from the protein structure and gene sequences such as cell-signaling are the main factors of human disease. When it comes to the topic of human disease breast cancer and sickle cell anemia have been the most prevalent. The importance of these topics in reference toRead MoreSickle Cell Anemia Is The Most Common Form Of The Disease1108 Words   |  5 PagesSickle Cell Anemia is a genetic disorder dealing with the hemoglobin within the red blood cells the individual has hemoglobin S (1). This causes the red blood cell to become gelatinous when deoxygenated (2). The Sickle Cell gene needs to be inhered from both of the parents; otherwise the individual will only carry the Sickle Cell trait. If the sickle cell trait is carried by an individual they can be asymptomatic. This individual can, however, transfer the gene abnormality to any offspring that theyRead MorePharmacogenomics Of Sickle Cell Disease1444 Words   |  6 PagesPharmacogenomics of Sickle Cell Disease Abstract Hydroxyurea is a treatment therapy that is currently used to treat sickle cell disease. There are a total of 23 single nuclear polymorphisms (SNPs) that are involved with sickle cell disease. When hydroxyurea is given at an optimal maximum dose, it will act on the BCL11A gene and increase the fetal hemoglobin concentrations. There are a total of 5 SNPs that are associated with the BCL11A gene. Some parameters that were observed are differences inRead MoreAnatomy And Physiology : Sickle Cell Disease Essay910 Words   |  4 PagesPaper – Sickle cell disease Sickle cell disease, also called sickle cell anemia is a group of disorders that affects the molecule in red blood cells that deliver oxygen to the cells. Approximately 100,00 people in America are affected by this disease. Sickle cell disease is an inherited disease, which means it is passed from parents to their children. This disease occurs mainly in people if African, middle eastern, Mediterranean, and Indian decent. People who are born with sickle cell diseaseRead MoreSickle Cells Anaemia And The Sickle Cell Trait910 Words   |  4 Pages UNDERSTANDING SICKLE CELL ANAEMIA AND THE SICKLE CELL TRAIT Introduction Sickle Cell Anaemia is the commonest of most severe form of Sickle Cell Disease. SCD is a collective term for hereditary haemoglobinopathies caused by the inheritance of a mutated haemoglobin allele (sickle haemoglobin-HbS) in the erythrocytes. The HbS mutation is caused by a Valine to Glutamic acid substitution at the 6th amino acid of the ÃŽ ²-globin chain. (Harmon et al., 2012)The first known case of SCD in the western worldRead MoreSickle-Cell Anemia531 Words   |  3 Pages Sickle-Cell Anemia is an inherited, chronic blood disease in which the body produces abnormally shaped red blood cells. When the blood cells become crescent/sickle shaped, they are unable to deliver adequate amounts of oxygen to other cells. Also, these unusual â€Å"sickle† cells block blood pathways to the limbs and organs, limiting the amount of blood flowing throughout the body. It causes pain, organ damage, and anemia (low blood count). Unfortunately, however, when sufferers are born with this di seaseRead MoreVaso-Occlusive Events In Sickle Cells Case Study746 Words   |  3 Pagespain common in sickle cell patients; it is a result of the adhesion of cells to the endothelial lining. While leukocytes play a role in vaso-occlusive events, erythrocyte activity plays an even bigger role. It was discovered that the receptors on the erythrocytes and the endothelial cell were responsible for the mediation of the adhesion of erythrocytes to the endothelial lining (Stuart; Nagel, 2004). The adhesions of these cells to the cell wall is what leads to inflammatory disease, and certain types